Over the past two decades, spectacular advances have been made in our understanding of the molecular genetics of cancer, leading to the pursuit of identifying genes that, when mutated, result in an increased susceptibility to the disease. In Cancer Susceptibility: Methods and Protocols, experts in the field bring together the most recent technological developments for identifying and screening cancer susceptibility genes. Divided into two clear sections, the book begins with gene identification, which updates and informs scientists working at identifying novel cancer susceptibility genes, while the second part deals with mutation screening technologies that aid scientists and clinicians working to translate this knowledge into the clinic. Written in the highly successful Methods in Molecular Biology? series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Susceptibility: Methods and Protocols is a timely collection that seeks to provide researchers with the tools to predict and combat this terrible disease.

From the reviews:

"This well-written and concise book is very timely, given the significant advances in the understanding of molecular genetics of cancer over the past two decades that led to the identification of genes which, when mutated, result in increased susceptibility to disease. ? It is written for scientists and clinicians ? . This book will be valuable resource for students, scientists, clinical oncologists, and other researchers interested in learning about cancer susceptibility." (Omer Iqbal, Doody's Review Service, February, 2011)

"Michelle Webb is attempting to give the readers the tools to achieve just that in the oncology field. The book provides up to date protocols and guides aimed at identification of mutations in the known cancer susceptibility genes as well as guides on how to search new ones. ? this book provides valuable and relevant information about susceptibility genes analysis and I'm sure it won't spend too much time just lying on the shelf in any research or clinical lab in this field." (J. Markus, Neoplasma, February, 2011)

"Cancer susceptibility methods and protocols is an up to date book illustrating a collection of molecular protocols intended to represent the basic and advanced molecular techniques which used to identify and screen for cancer susceptibility genes. ? This book deserves great praise for the readable presentation of this complex field. ? a valuable authoritative and accessible resource for the current molecular methods used to explore and screen for cancer genes. Both cancer biologists and very specialized clinicians ? will find this book a good reference." (Abeer Alsaegh and Diana M. Eccles, Human Genetics, Vol. 131, 2012)