In this groundbreaking, global analysis of the relationship between climate change and human health, Hans Baer and Merrill Singer inventory and critically analyze the diversity of significant and sometimes devastating health implications of global warming. Using a range of theoretical tools from anthropology, medicine, and environmental sciences, they present ecosyndemics as a new paradigm for understanding the relationship between environmental change and disease. They also go beyond the traditional concept of disease to examine changes in subsistence and settlement patterns, land-use, and lifeways, throwing the sociopolitical and economic dimensions of climate change into stark relief. Revealing the systemic structures of inequality underlying global warming, they also issue a call to action, arguing that fundamental changes in the world system are essential to the mitigation of an array of emerging health crises link to anthropogenic climate and environmental change.