Hydrocephalus is one of the most common diseases of pediatric and adult neurosurgery. With the introduction of modern neurosurgical procedures, this disease has become a life-long problem.  Even with optimal treatment, there is still significant morbidity and mortality along with a significant cost to the medical system.  This has caused patients and their families to demand improvements in treatments and forced clinicians to evaluate their treatments in large consortiums while utilizing both genetics and technology to improve outcomes or avoid placement of shunt all together.

This text is designed to present the current treatments for hydrocephalus across the lifespan.  The foundation for understanding cerebral spinal fluid (CSF) abnormalities begins with the understanding of physiology and pathogenesis of disease.  These chapters are written by published experts in the field and detail the significant advances in the detection of CSF abnormalities.  This section will discuss the current advances in imaging and current research in biomarkers for both pediatric and adult patients. We will then systematically discuss the treatment of both pediatric and adult CSF disorders.  These will be broken down by cause, since  the physiology of each can be different.  We will end the book with a discussion both of the technological advances and a discussion of consortiums and how they have advanced treatment of this chronic disease.

This book is designed to provide the current state-of-the-field for CSF disorders that occur across the lifespan. The authors of the following chapters are true content experts and provide their accumulated knowledge, experience, and wisdom in addition to a thoughtful view forward. We begin with a discussion of the ventricles themselves, with changes in the ependyma that occurs throughout development and as the brain matures and then ages.  Pathophysiological changes and their role in hydrocephalus of various etiologies are considered.  Alterations in CSF composition, physiology, and flow are also discussed in the context of neurodevelopment and neurodegeneration. "Cerebrospinal Fluid Disorders: Lifelong Implications allows an important, in-depth insight and knowledge extraction for physicians as well as researchers interested in specific aspects of hydrocephalus research and treatment along with guidance to future research and its potential impact on the health care system." (Petra M. Klinge, Neurosurgery, Vol. 85 (3), September, 2019)