Persons with disabilities in Cameroon are incessantly complaining of being marginalized in different sectors of the society through neglect, stigmatization and disrespect. The primary objective of this book is to raise the general awareness of the respect of the human rights of persons with disabilities in Cameroon. This study aims at pointing out the hurdles that beset the enforcement of the rights of persons with disabilities in Cameroon from a human right-based approach. Persons living with impairments are a group of persons that are vulnerable in Cameroon because disability comes with so many challenges such as discrimination and violence within the society, family and institutional settings. In the face of this situation, this book has taken the responsibility to strongly call for an urgent need for stakeholders concerned with the conditions of persons with impairments to adequately exercise their responsibilities in consideration of human rights precepts.